ea0021p157 | Diabetes and metabolism | SFEBES2009
Gardiner James
, Campbel Daniel
, Kent Aysha
, Patterson Michael
, Ghatei Mohammed
, Bloom Stephen
, Bewick Gavin
Background and aims: Ghrelin is the only known peripheral hormone, which increases food intake. It is released from the stomach and is thought to function as a meal initiator and signal of energy deficit. We used bacterial artificial chromosome transgenesis to generate a mouse model with increased ghrelin expression and production in stomach and brain. These mice exhibited increased circulating bioactive ghrelin and as expected were hyperphagic and glucose intolerant. We hypot...